报告人：Jean-François Paquin

主持人：储玲玲特聘研究员

时间：2024年10月30日（星期三）11:00

地点：复合材料创新协同大楼第二报告厅

报告人介绍：JEAN-FRANÇOIS PAQUIN studied chemistry at Université Laval (Quebec City, Canada) where he graduated with a B.Sc. degree in 1999. In 2004, he received his Ph.D. degree at the University of Toronto (Canada). After a postdoctoral stay at the ETH Zürich (Switzerland), he was appointed assistant professor in 2005 at Université Laval (Quebec City, Canada) as a Tier 2 Canada Research Chair in Organic and Medicinal Chemistry (2005-2010). In 2010, he was promoted to associate professor and his Canada Research Chair in Organic and Medicinal Chemistry renewed (2010-2015). He was promoted to Full Professor in 2014.He has been awarded, in 2015, a Humboldt Research Fellowship for a 6-month stay at the KIT in the group of Professor Anne S. Ulrich (Karlsruhe, Germany). In 2016, he received the Keith Fagnou Award from the Canadian Society of Chemistry. His research interests include the development of novel methodologies for the synthesis of organofluorine compounds and their applications for the preparation of bioactive fluorinated compounds or fluorinated biological probes. Jean-François has co-authored more than one hundred publications in addition to fifteen book chapters. He has presented more than one hundred invited lectures. Jean-François is a member of the Canadian Society for Chemistry (CSC) and the American Chemical Society (ACS). He has been a member-at-large on the executive committee of the Fluorine Chemistry Division of the ACS from 2013 to 2022. Finally, he was one of the co-hosts for the International Symposium on Fluorine Chemistry that took place in Quebec City in July 2023.

报告摘要：Since its discovery, the pentafluorosulfanyl group (SF5) has been attracting its share of attention in organic chemistry. Considered as a “super CF3”, the SF5 group has interesting properties including, amongst others, a large dipole moment, a high lipophilicity and a strong electron-withdrawing capacity. These characteristics make it a substituent of choice in medicinal chemistry, agrochemistry and material sciences. In that context, the development of novel synthetic methods for the preparation of pentafluorosulfanylated molecules in an important objective.

This presentation will describe some of our recent efforts towards the development of novel synthetic strategies for the preparation of SF5-containing molecules.