报告人：Prof. Bruce Arndtsen

主持人：储玲玲 特聘研究员

时间：2024年10月15日（星期二）10:00

地点：复合材料协同创新大楼第二报告厅

报告人简介：Bruce Arndtsen is a James McGill Professor of Chemistry at McGill University. He obtained his undergraduate chemistry degree from Carleton College in 1988, followed by a Ph.D. in 1993 from Stanford University with Prof. Lisa McElwee-White, and postdoctoral research from 1993-1995 at University of California, Berkeley with Prof. Bob Bergman.  In 1995, he began his independent career at McGill University, where he moved to his current position of full professor. Research in his laboratory is at the intersection of metal catalysis, synthesis, and sustainability. This includes recent thrusts using photochemistry and electrochemistry in palladium catalysis, carbonylative electrophile synthesis, C-H functionalization, chiral anions in asymmetric catalysis, new classes of cycloaddition reactions, and multicomponent synthesis. During his career, he has been named a Canadian Research Chair at McGill (Tier I and Tier II equivalents), received two DuPont Research Awards, an NSERC Accelerator Award, and in 2021 received the Alfred Bader Award in Organic Chemistry by the Canadian Society for Chemistry.

报告摘要：The ability of transition metal catalysts to mediate new bond forming reactions has had a dramatic impact on modern molecular synthesis. Nevertheless, a central feature in these reactions is need to balance of reverse operations on the catalyst so it is regenerated at the end of each cycle of product formation, which can limit catalytic activity and the scope of many transformations. This talk will describe our efforts to address these challenges by introducing alternative, often renewable, energy sources into catalysis, and from this create new bond forming reactions. These include using visible light excitation directly on active palladium catalysts to drive the oxidative addition/reductive elimination cycle in coupling reactions independent of the classical limits in thermal catalysis, or the use of electrochemistry to change the nature of the metal throughout the cycle.[1] Combining these with the favored energetics of carbon monoxide conversion to carboxylic acid derivatives can be used to drive the build-up of reactive products from stable reagents. The use of this chemistry to create ambient temperature and general catalysts for carbonylation reactions, multicomponent transformations, acyl halide or even super-electrophile formation, or new avenues to C-H bond functionalization, will be discussed, as will the mechanistic origins of these influences, and their ability to enable the use of earth abundant catalysts in traditionally precious metal catalyzed reactions.