报告题目：Hydrogen-Mediated C-C Bond Formation

报 告 人：Michael J. Krische 教授

报告时间：2019年6月27日（周四）10:00

报告地点：先进低维材料中心学术交流室（2号学院楼西2632）

主 持 人：储玲玲 特聘研究员  

报告人简介：
Professor Michael J. Krische, PhD, FRSC, FAAAS

University of Texas at Austin, Department of Chemistry

讲座摘要：

    Stereo- and site-selective methods for the byproduct-free modification of unprotected organic compounds that occur through the addition or redistribution of hydrogen are natural endpoints in the advancement of methods for efficient, green chemical synthesis. Progress toward this goal requires a departure from reactants that embody non-native structural elements, including stoichiometric organometallic reagents, directing/protecting groups and chiral auxiliaries. Professor Michael J. Krische (B.S. UC Berkeley; PhD Stanford University) has developed a broad, new family of C-C bond formations that merge the characteristics of catalytic hydrogenation and carbonyl addition. Hydrogenation or transfer hydrogenation of π-unsaturated reactants in the presence of C=X (X = O, NR) bonds delivers products of carbonyl or imine addition. In related hydrogen auto-transfer reactions, alcohols served dually as reductants and carbonyl proelectrophiles, enabling direct conversion of lower alcohols to higher alcohols. Such hydrogen-mediated C-C bond formations define a departure from the use of stoichiometric organometallic reagents, and the issues of safety, selectivity, and waste associated with their use.

Reviews & Perspectives: (a) Ketcham, J. M.; Shin, I.; Montgomery, T. P.; Krische, M. J. Angew. Chem. Int. Ed. 2014, 53, 9142. (b) Feng, J.; Kasun, Z. A.; Krische, M. J. J. Am. Chem. Soc.2016, 138, 5467. (c) Nguyen, K. D.; Park, B. Y.; Luong, T.; Sato, H.; Garza, V. J.; Krische, M. J. Science2016, 354, 300. (d) Kim, S. W.; Zhang, W.; Krische, M. J. Acc. Chem. Res. 2017, 50, 2371.