CALM TALK 046 | Synthetic Biology Approaches toward Diverse Protein-Based Materials
发布人:张妮  发布时间:2017-05-18   

主题:Synthetic Biology Approaches toward Diverse Protein-Based Materials
主讲人:Dr.Fei SUN 




主讲人简介Dr. Fei Sun is currently an Assistant Professor at the Department of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology. He worked as a postdoctoral researcher at the Department of Chemical Engineering, Caltech from 2012 to 2014. He obtained Ph.D. degree at the University of Chicago in 2012 and B.S. degree at Peking University in 2007 with the work recognized by several awards including Chicago Biomedical Consortium Scholar Award and The Everett E. Gilbert Memorial Prize in Organic Chemistry.

讲座摘要The synthesis of molecular systems with precise structural and functional control constitutes a fundamental challenge for molecular engineering. Development of the ability to construct complex biomolecular architectures provides a solution to this challenge. 

Dr Sun’s team is interested in a new category of protein chemistry, namely, genetically encoded click chemistry (GECC), which can covalently stitch together protein molecules with high specificity and efficiency under mild physiological conditions. They have demonstrated that a prototypical GECC, SpyTag-SpyCatcher chemistry, enabled cellular synthesis of macromolecules while exerting precise control over the fundamental properties of these molecules including length, sequence, stereochemistry and topology. The same chemistry further led to the creation of bioactive and photo-responsive protein materials for three dimensional stem cell culturing and controlled stem cell/protein release. 

Given its potential in molecular engineering and materials science, they will continue to enrich and diversify the GECC toolbox through directed evolution and other protein engineering methods. By bridging the two fields, synthetic biology and materials science, GECC provides us with enormous opportunities to create new protein materials for a variety of applications ranging from regenerative medicine to green mining.